FINDING A PHYSICIAN

AL amyloidosis screening¹¹

The diagnostic algorithm should always begin with a monoclonal protein screen to assess for AL amyloidosis. If AL amyloidosis is suspected, initiate laboratory testing to assess for monoclonal protein production and evidence of vital organ involvement or dysfunction. In AL amyloidosis, free lambda or free kappa levels are elevated.

ASNC Guidance for ^99mTc-PYP Grading¹⁴

1. Quantitative heart to contralateral lung (H/CL) ratio of uptake at one hour: ATTR-positive if ≥1.5 in the presence of myocardial PYP uptake confirmed on SPECT
2. Semi-quantitative, visual scoring method to compare myocardial uptake to bone uptake at three hours: ATTR‑positive if ≥Grade 2

Review ASNC Guidance

Biopsy of affected tissues can detect TTR amyloid deposition^2,5,10-12